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In addition, studies reporting an intent-to-treat analysis or with #links# statistically significant strong levels of association (>80% reduction) received 0.5�C1.0 grade increase. Any study with a final grade of very low was excluded on the basis of inadequate study quality. Meta-analyses were generated where data were available from more than one study for an outcome. For cluster randomised tria
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Continuous variables that were not normally distributed were expressed as median (interquartile range). Categorical variables were expressed as numbers (percentages). Continuous variables were compared using one-way ANOVA or the Kruskal�CWallis test. Categorical variables were compared using the chi-square test or Fisher's exact test. To obtain independent predictors of severe carotid atherosclero
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